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KMID : 0811719980020010001
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Korean Journal of Physiology & Pharmacology
1998 Volume.2 No. 1 p.1 ~ p.7
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Ca2＋-Dependent Exocytosis in Endocine, Exocrine, and Nonsecretory Cells
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Haruo Kasai
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Abstract
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Exocytosis in various secretory cells is regulated by Ca2＋ signaling. In this minireview, I will introduce our recent approach, which we have termed comparative biology of exocytosis, to the study of Ca2＋-dependent
secretion in such cells. In this
approach, we quantify and compare the secretory process in different cell types (neurons, endocrine cells, and exocrine cells) with the same techniques. This approach benefits from the fact that the biochemistry and ultrastructure of these cells
are
relatively well characterized and it is expected to be particularly revealing because of the marked differences in the properties of exocytosis thought to exist among different secretory cells. The first part of this article deals with the
mechanism
by
which Ca2＋ signaling regulates exocytosis in exocrine cells, and the second part deals more generally with the diversity in the kinetics of the exocytotic machinery among different types of cells and secretory vesicles.
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KEYWORD
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